AUTOIMMUN KASALLIKLARDA ENDOTELIAL DISFUNKSIYA VA UNING TROMBOGENEZDAGI ROLI
Keywords:
autoimmun kasalliklar, gemostaz, tromboz, antifosfolipid sindrom, lupus antikoagulyanti, D-dimer, antitrombin III.Abstract
Ushbu maqolada autoimmun kasalliklarda gemostaz tizimining o‘zgarishlari, ularning patogenetik mexanizmlari, immun yallig‘lanish bilan bog‘liqligi va klinik ahamiyati yoritilgan. Tadqiqot natijalari shuni ko‘rsatadiki, autoimmun jarayonlarda koagulyatsion va antikoagulyant tizim o‘rtasidagi muvozanat buzilishi giperkogulyatsiya, tromboz va gemorragik sindromlarga olib keladi. Gemostazdagi bu o‘zgarishlar kasallikning og‘irlik darajasini belgilab, trombotik asoratlar xavfini oshiradi.
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